Supporting Articles and Research

Dierickx CC, Mazer JM, Sand M, Koenig S, Arigon V. Safety, Tolerance, and Patient Satisfaction with Noninvasive Cryolipolysis.

Dermatol Surg. 2013 Aug;39(8):1209-16.

Key Points:

• 86% of patients showed visible improvement to the treated area.
• 82% of patients would recommend the procedure to others.
• Effectiveness is visually supported by photographic evidence.

Dover, MD, J. Burns, MD, S. Coleman, MD, R. Fitzpatrick, MD, J. Garden, MD, D. Goldberg, MD, R. Geronemus, MD, S. Kilmer, MD, F. Mayoral, MD, E. Tanzi, MD, R. Weiss, MD, and B. Zelickson, MD

Key Points:

• Visible Improvement, and Effectiveness are demonstrated and supported with photographic evidence as well as ultrasound evidence.
• Cryolipolysis results in reductions in subcutaneous fat volume without damage to the surrounding tissues.
• Explicitly states that Cryolipolysis results in cold-induced apoptotic fat cell death.

Manstein D, Laubach H, Watanabe K, Farinelli W, Zurakowski D, Anderson RR. Selective Cryolipolysis: A Novel Method of Non-Invasive Fat

Removal. Lasers in Surgery and Medicine. 2008; 40:595-604.

Key Points:

• First published paper on Cryolipolysis
• Proof of concept through initial pig study data
• Prolonged, controlled, local skin cooling can induce selective damage and subsequent loss of subcutaneous fat
• No damage to overlying skin or significant change in lipid levels with prolonged exposure to cooling
• Established Harvard Med School/Mass General Hospital relationship with ZELTIQ – “Science by Harvard, Technology by ZELTIQ”

Klein K, Zelickson B, Riopelle JG, Okamoto E, Bachelor EP, Harry RS, Preciado JA. Non-Invasive Cryolipolysis for Subcutaneous Fat

Reduction Does Not Affect Serum Lipid Levels or Liver Function Tests. Lasers in Surgery and Medicine. 2009; 41(10):785-790.

Key Points:

• 40 subjects treated on the flanks
• Serum lipid levels and liver function tests measured at baseline and post-treatment
  (1 day, 1 week, 4 weeks, 8 weeks, and 12 weeks)
• No meaningful trends or changes observed in cholesterol, triglycerides, and liver function test analytes

Coleman SR, Sachdeva K, Egbert BM, Preciado J, Allison J. Clinical Efficacy of Noninvasive Cryolipolysis and Its Effects on Peripheral Nerves.

Aesthetic Plastic Surgery. 2009; 33(4):482-488.

Key Points:

• 9 participants were evaluated at baseline, at 2 and at 6 months post-procedure
• Transient reduction in sensation occurred in 6 of 9 participants assessed by neurologic evaluation
• All sensation returned by a mean of 3.6 weeks after treatment
• Biopsies showed no long-term change in nerve fiber structure
• No lasting sensory alterations or observations of skin damage

Bernstein EF, Long-term efficacy follow-up on two cryolipolysis case studies: 6 and 9 years post-treatment.

Journal of Cosmetic Dermatology. 2016. Early View (online version of record published before inclusion in an issue)

Key Points:

• Durable CoolSculpting treatment results are shown at 6 and 9 years post-treatment even with weight fluctuations.
• First publication to report long-term follow-up and results with a non-surgical fat reduction device up to 9 years.

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